Effective Data Augmentation, Filters, and Automation Techniques for Automatic 12-Lead ECG Classification Using Deep Residual Neural Networks.

Automatic electrocardiogram (ECG) analysis plays a critical role in early detection and diagnosis of cardiac abnormalities and diseases. Data augmentation and automation strategies have been proposed to enhance the robustness of the machine and deep learning model for the classification of cardiac abnormalities. Here we propose 15 data augmentation and 6 filters, and an automation method using an end-to-end deep residual neural network (ResNet) model for automatic cardiac abnormalities detection from 12-lead ECG recordings. We evaluate the effectiveness of data augmentation/filtering and automation techniques using the proposed ResNet-based model on the China Physiological Signal Challenge (CPSC) dataset consisting of 9 diagnostic classes. The average F1 scores across 9 classes on the CPSC dataset trained with three data augmentation (baseline wander addition, dropout, and scaling) and a filter (sigmoid compression) were significantly higher than that without using augmentation/filters (baseline). The highest average F1 score with sigmoid compression method was significantly higher (relative improvement of 2.04 %) than the baseline while horizontal and vertical flipping augmentations were detrimental to the classification performance. Additionally, the results show that the random combination of four selected data augmentation and filter using the modified RandAugment technique provided a significantly higher average F1 score (relative improvement of 2.54 %) compared to the baseline. The proposed data augmentation, filters, and automation techniques provide an effective solution to improve the classification performance of the end-to-end deep learning model from ECG recordings without changing the model hyperparameters and structure.

Sharpening Working Memory With Real-Time Electrophysiological Brain Signals: Which Neurofeedback Paradigms Work?

Growing evidence supports the idea that the ultimate biofeedback is to reward sensory pleasure (e.g., enhanced visual clarity) in real-time to neural circuits that are associated with a desired performance, such as excellent memory retrieval. Neurofeedback is biofeedback that uses real-time sensory reward to brain activity associated with a certain performance (e.g., accurate and fast recall). Working memory is a key component of human intelligence. The challenges are in our current limited understanding of neurocognitive dysfunctions as well as in technical difficulties for closed-loop feedback in true real-time. Here we review recent advancements of real time neurofeedback to improve memory training in healthy young and older adults. With new advancements in neuromarkers of specific neurophysiological functions, neurofeedback training should be better targeted beyond a single frequency approach to include frequency interactions and event-related potentials. Our review confirms the positive trend that neurofeedback training mostly works to improve memory and cognition to some extent in most studies. Yet, the training typically takes multiple weeks with 2-3 sessions per week. We review various neurofeedback reward strategies and outcome measures. A well-known issue in such training is that some people simply do not respond to neurofeedback. Thus, we also review the literature of individual differences in psychological factors e.g., placebo effects and so-called "BCI illiteracy" (Brain Computer Interface illiteracy). We recommend the use of Neural modulation sensitivity or BCI insensitivity in the neurofeedback literature. Future directions include much needed research in mild cognitive impairment, in non-Alzheimer's dementia populations, and neurofeedback using EEG features during resting and sleep for memory enhancement and as sensitive outcome measures.

Gauging Working Memory Capacity From Differential Resting Brain Oscillations in Older Individuals With A Wearable Device.

Working memory is a core cognitive function and its deficits is one of the most common cognitive impairments. Reduced working memory capacity manifests as reduced accuracy in memory recall and prolonged speed of memory retrieval in older adults. Currently, the relationship between healthy older individuals' age-related changes in resting brain oscillations and their working memory capacity is not clear. Eyes-closed resting electroencephalogram (rEEG) is gaining momentum as a potential neuromarker of mild cognitive impairments. Wearable and wireless EEG headset measuring key electrophysiological brain signals during rest and a working memory task was utilized. This research's central hypothesis is that rEEG (e.g., eyes closed for 90 s) frequency and network features are surrogate markers for working memory capacity in healthy older adults. Forty-three older adults' memory performance (accuracy and reaction times), brain oscillations during rest, and inter-channel magnitude-squared coherence during rest were analyzed. We report that individuals with a lower memory retrieval accuracy showed significantly increased alpha and beta oscillations over the right parietal site. Yet, faster working memory retrieval was significantly correlated with increased delta and theta band powers over the left parietal sites. In addition, significantly increased coherence between the left parietal site and the right frontal area is correlated with the faster speed in memory retrieval. The frontal and parietal dynamics of resting EEG is associated with the "accuracy and speed trade-off" during working memory in healthy older adults. Our results suggest that rEEG brain oscillations at local and distant neural circuits are surrogates of working memory retrieval's accuracy and processing speed. Our current findings further indicate that rEEG frequency and coherence features recorded by wearable headsets and a brief resting and task protocol are potential biomarkers for working memory capacity. Additionally, wearable headsets are useful for fast screening of cognitive impairment risk.

A Usability Study of Low-cost Wireless Brain-Computer Interface for Cursor Control Using Online Linear Model.

Computer cursor control using electroencephalogram (EEG) signals is a common and well-studied brain-computer interface (BCI). The emphasis of the literature has been primarily on evaluation of the objective measures of assistive BCIs such as accuracy of the neural decoder whereas the subjective measures such as user's satisfaction play an essential role for the overall success of a BCI. As far as we know, the BCI literature lacks a comprehensive evaluation of the usability of the mind-controlled computer cursor in terms of decoder efficiency (accuracy), user experience, and relevant confounding variables concerning the platform for the public use. To fill this gap, we conducted a two-dimensional EEG-based cursor control experiment among 28 healthy participants. The computer cursor velocity was controlled by the imagery of hand movement using a paradigm presented in the literature named imagined body kinematics (IBK) with a low-cost wireless EEG headset. We evaluated the usability of the platform for different objective and subjective measures while we investigated the extent to which the training phase may influence the ultimate BCI outcome. We conducted pre- and post- BCI experiment interview questionnaires to evaluate the usability. Analyzing the questionnaires and the testing phase outcome shows a positive correlation between the individuals' ability of visualization and their level of mental controllability of the cursor. Despite individual differences, analyzing training data shows the significance of electrooculogram (EOG) on the predictability of the linear model. The results of this work may provide useful insights towards designing a personalized user-centered assistive BCI.

Optimizing Prediction Model for a Noninvasive Brain-Computer Interface Platform Using Channel Selection, Classification, and Regression.

A brain-computer interface (BCI) platform can be utilized by a user to control an external device without making any overt movements. An EEG-based computer cursor control task is commonly used as a testbed for BCI applications. While traditional computer cursor control schemes are based on sensorimotor rhythm, a new scheme has recently been developed using imagined body kinematics (IBK) to achieve natural cursor movement in a shorter time of training. This article attempts to explore optimal decoding algorithms for an IBK paradigm using EEG signals with application to neural cursor control. The study is based on an offline analysis of 32 healthy subjects' training data. Various machine learning techniques were implemented to predict the kinematics of the computer cursor using EEG signals during the training tasks. Our results showed that a linear regression least squares model yielded the highest goodness-of-fit scores in the cursor kinematics model (70% in horizontal prediction and 40% in vertical prediction using a Theil-Sen regressor). Additionally, the contribution of each EEG channel on the predictability of cursor kinematics was examined for horizontal and vertical directions, separately. A directional classifier was also proposed to classify horizontal versus vertical cursor kinematics using EEG signals. By incorporating features extracted from specific frequency bands, we achieved 80% classification accuracy in differentiating horizontal and vertical cursor movements. The findings of the current study could facilitate a pathway to designing an optimized online neural cursor control.

A comprehensive review of EEG-based brain-computer interface paradigms.

Advances in brain science and computer technology in the past decade have led to exciting developments in brain-computer interface (BCI), thereby making BCI a top research area in applied science. The renaissance of BCI opens new methods of neurorehabilitation for physically disabled people (e.g. paralyzed patients and amputees) and patients with brain injuries (e.g. stroke patients). Recent technological advances such as wireless recording, machine learning analysis, and real-time temporal resolution have increased interest in electroencephalographic (EEG) based BCI approaches. Many BCI studies have focused on decoding EEG signals associated with whole-body kinematics/kinetics, motor imagery, and various senses. Thus, there is a need to understand the various experimental paradigms used in EEG-based BCI systems. Moreover, given that there are many available options, it is essential to choose the most appropriate BCI application to properly manipulate a neuroprosthetic or neurorehabilitation device. The current review evaluates EEG-based BCI paradigms regarding their advantages and disadvantages from a variety of perspectives. For each paradigm, various EEG decoding algorithms and classification methods are evaluated. The applications of these paradigms with targeted patients are summarized. Finally, potential problems with EEG-based BCI systems are discussed, and possible solutions are proposed.